Mesotherapy- 

also known as biorejuvenation or biorevitalization,  is a cosmetic procedure in which medications (vasodilators, antibiotics), vitamins, enzymes (collagenase, hyaluronidase), plant extracts, hormones (calcitonin, thyroxin), and homeopathic substances are injected 1-4 mm into the skin into the fat to tighten skin as well as remove excess fat.  The technique was developed by Michel Pistor, a French physician in 1952, and was originally used as a pain relief technique.  The injections are repeated every 7 days and repeated 3-15 times.  The evidence for this procedure has not shown significant benefit for skin rejuvenation.  A 2012 study (Int J Dermatol 2012 Aug;51(8):913-919) of 6 people receiving the treatment for 6 months showed no improvement in wrinkles and a 2008 study found no reduction in thigh size.